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Disease responsible for three of the worst pandemics in history 

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Disease responsible for three of the worst pandemics in history

Answer

PLAGUE


Definition

That which smites, wounds, or troubles; a blow; a calamity; any afflictive evil or torment; a great trail or vexation.
An acute malignant contagious fever, that often prevails in Egypt, Syria, and Turkey, and has at times visited the large cities of Europe with frightful mortality; hence, any pestilence; as, the great London plague.
To infest or afflict with disease, calamity, or natural evil of any kind.
Fig.: To vex; to tease; to harass.